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Neuroleptic malignant syndrome (NMS) which can cause Dying. Tell you Health care provider at once When you've got any of the subsequent indicators of NMS: high fever

Breathing difficulties (respiratory depression) that can cause Dying and opioid withdrawal can happen if You begin getting or end having other medicines whilst taking Promethazine Hydrochloride and Codeine Phosphate Oral Remedy, together with:

g., These with proof of increased intracranial tension or Mind tumors), promethazine HCl and codeine phosphate oral Option may possibly cut down respiratory generate, plus the resultant CO2 retention can additional enhance intracranial stress. Also, opioids make adverse reactions that may obscure the medical class of clients with head accidents.

Codeine is thought for being substantially excreted via the kidney, and the chance of adverse reactions to this drug could be bigger in clients with impaired renal perform.

Get hold of nearby state Expert licensing board or state managed substances authority for info on how to forestall and detect abuse or diversion of this solution.

Steer clear of using promethazine HCl and codeine phosphate oral solution in adolescents 12 to eighteen a long time of age who produce other chance aspects which will boost their sensitivity to your respiratory depressant consequences of codeine.

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The codeine in promethazine HCl and codeine phosphate oral Remedy may possibly lead to spasm on the sphincter of Oddi, resulting in a rise in biliary tract pressure.

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Observational experiments have shown that concomitant utilization of opioid analgesics and benzodiazepines increases the chance of drug-relevant mortality when compared with usage of opioids on your own.

two.one Critical Dosage and Administration Recommendations Administer promethazine HCl and codeine phosphate oral Answer from the oral route only. Usually use an accurate milliliter measuring product when administering promethazine HCl and codeine phosphate oral Alternative to make certain that the dose is calculated and administered accurately.

Serotonin Syndrome Inform sufferers that promethazine HCl and codeine phosphate oral Resolution could bring about a exceptional but potentially life-threatening affliction ensuing from concomitant administration of serotonergic medicine.

five.14 Threat of Paradoxical Reactions, like Dystonias Promethazine HCl and codeine phosphate oral Resolution includes promethazine, a click here phenothiazine. Phenothiazines are connected with dystonic reactions, especially in pediatric patients which have an acute ailment linked to dehydration.